Compared to adults, the elimination half-life in pediatric patients was more variable, averaging 40 minutes (range: 20 to 75 minutes). Prolongation of the half-life to 1.3 hours in patients with moderate hepatic impairment and 2.4 hours in severely impaired patients. Initial distribution half-life is 4 to 11 minutes and the terminal half-life is 40 to 80 minutes. Elimination of radiolabeled drug is essentially complete within 72 hours, with 90% to 95% of the radioactivity appearing in urine and 5% to 10% in the feces. Route of eliminationįlumazenil is completely (99%) metabolized. ![]() The major metabolites of flumazenil identified in urine are the de-ethylated free acid and its glucuronide conjugate. Flumazenil is completely (99%) metabolized. Protein binding is reduced in patients with hepatic cirrhosis. ![]() Protein binding is approximately 50%, mostly (66%) to albumin.
0 Comments
Leave a Reply. |